Therapy Systems

Sonalleve MR-HIFU

Therapy platform

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Extend your options in women’s health and oncology. Sonalleve MR-HIFU opens up non-invasive alternatives to traditional surgical treatments of uterine fibroids and enables non-invasive palliative pain treatment of bone metastases.

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In the later stages of their disease, many cancer patients develop bone metastases, which can cause severe and debilitating pain. UMC Utrecht is using innovative Sonalleve MR-HIFU therapy to treat non-invasive palliative pain treatment of bone metastases.

Dr. Merel Huisman, radiologist
Professor Maurice van den Bosch, Chairman Department of Radiology & Nuclear Medicine

"With Sonalleve MR-HIFU we have the technique to remove the uterine fibroids without surgery. I think Sonalleve MR-HIFU is a very promising technique because it can be done as an outpatient treatment. This makes good financial sense and patients tolerate it very well".

Professor Klaus Diedrich, director of the Obstetrics and Gynecology Clinic at University Hospital Schleswig-Holstein Lübeck, Germany

"We started to treat our cancer patients for their pain from bone metastasis with the Sonalleve MR-HIFU system. The results had been exciting from the beginning; most of our patients experience a very significant pain relief within a week of having the procedure".

Professor Nandita deSouza, co-director of The Institute of Cancer Research, Sutton, Surrey, UK

"With the new DISC skin cooling of the Sonalleve MR-HIFU system we can treat our fibroid patients much faster than before.* We also started to treat larger fibroids and can now offer this non-invasive option to more patients".

* Difference between Sonalleve MR-HIFU with R3.2 software without DISC and with software R3.5 software and DISC

Professor Markus Zähringer, medical director of the Diagnostic and Interventional Radiology Clinic, Marienhospital, Stuttgart, Germany.

Specifications Show all

Philips MR systems
Achieva: 1.5T, 3.0T, and 3.0T TX T
Achieva SmartPath to dStream: 1.5T and 3.0T TX T
Multiva 1.5 T
Ingenia: 1.5T and 3.0T T
Ingenia CX: 1.5T and 3.0T T
Configuration overview
Dedicated trolley-tabletop
The separate trolley is positioned over the lowered MR patient support
Save time with patient preparation outside the MR room
Robotic transducer positioning system with five degrees of freedom
HIFU therapy transducer
Philips proprietary design, model SX140 mm
Focal length 140 mm
Sonalleve therapy console
Hardware and software for treatment planning, temperature mapping, ablation feedback, therapy guidance and communication with the Philips MR scanner
Heating method
Volumetric heating
Focal spot is moved rapidly in concentric circles to reach homogenous temperature over macroscopic volume (treatment cell) in a short time
Treatment cell sizes
Focus trajectories use heat diffusion to reach maximal ablation efficiency. Multiple cell sizes with diameters of 4, 8, 12, 14 and 16 mm are available. Cell length is usually 2.5 times the diameter
DIrect Skin Cooling
Patient’s skin is kept at a constant temperature of about 20 °C
Direct coupling
For cooling efficiency, the patient is positioned directly onto the membrane; most patients don’t require a gel pad
Real-time feedback
Temperature and thermal dose are measured in real time and used to adjust sonication parameters during a sonication event to achieve desired ablation temperature and volume, independent of local variations in tissue properties
Real-time HIFU-MR interface
System and MR console
Between Sonalleve MR-HIFU and the Achieva MR console
Rapid and dedicated interface allows fast scanner control and image retrieval to support real-time feedback
Imaging sequences
Treatment planning
On 3D diagnostic MR images
All standard diagnostic imaging sequences of the MR system are available for treatment planning
Dedicated ExamCards are provided for HIFU applications
Dual Mode Thermometry
Full workflow integration of novel fat tissue thermometry based on T2-weighted MR imaging data measuring cumulative heating over the whole treatment duration with PRFS thermometry for target heating
PRFS temperature monitoring
FFE-EPI-based phase sensitive MR sequences
Temperature and thermal dose maps are calculated based on the temperature sensitive Proton Resonance Frequency Shift induced phase difference
Refresh rate of thermal images
Six slices every 3.5 sec
Three coronal and one sagittal slice through focus, two slices freely positioned, such as near field and far field sec
Temperature changes ±1 °C
T2-based temperature monitoring
Reproducible and long-term
Based on T2-weighted MRI
Calibrated absolute temperature measurement, for adipose tissue
Fully integrated and automated treatment workflow
±2 °C
Software and user interface
Dedicated tools
Protocols and ExamCards for Philips MR systems
Excellent scanning efficiency and ease of use
Treatment planning
Based on 3D diagnostic MR images
Tools for efficient planning of treatment volumes, beam paths, and transducer positions
Tools to verify a beam path free of obstruction to maintain patient safety
Auto-population tool
Calculates the size and position of multiple treatment cells to cover the desired treatment volume
Beam shaping
OAR (Organ Avoidance Region) or Critical OAR regions can be drawn to protect sensitive regions, such as scars and skin folds from high ultrasound exposure
Thermal maps
Real-time PRFS temperature maps and thermal dose maps overlaid on anatomical MR images for continuous treatment monitoring
Heating curve
Displays the temperature and thermal dose over time during a single sonication